I've wanted to try this for a long time and I finally took the plunge! I have successfully put fleece as the backing of a cotton quilt! Yes--it works!
I got this Star Wars panel at a garage sale a couple years ago, and it recently resurfaced from the inner-most chamber of my stash. It was calling to me to make a hurry-up blanket for my young Padawan son for his impending birthday.
Make sure your cottons are all prewashed and preshrunk. I added a colorful scrap border and a regular border. I continued the fire theme by freelancing some free-motion flames in the scrap border.
Using fleece on the back eliminates the need for batting, and it comes up to 60 inches wide, so I didn't even piece this back. Two yards of length was all I used. With a fleece back, you can get away with less quilting than with cottons too. I think the best results would be obtained with a high quality fleece. I used an anti-pill fleece.
I layed out the fleece without stretching it, and then layed out the top over it. I pin basted well, to reduce stretching that could occur during quilting. I think you could add a regular fabric binding, but for softness, I opted to do a fold-over binding. It worked really well.
I rotory cut the fleece edge 3/4 " larger than the quilt top. Fleece doesn't fray, so I think a straight edge would be fine, but I used the scolloped blade on my rotary cutter (it was a little challenging to use a wavy blade againt a straight ruler). Then, you just fold it over in place and sew it down. It would be essential to use a walking foot with fleece.
My fold-over binding corners are always less than stellar, but fleece is so forgiving, that you can easily push the corners into place. I sewed to within a couple of inches of the corner from both ways, snipped off the pointed corner, and then worked it into a suitable corner shape, and stitched it up. Easy!
Melissa finished the 30's quilt that she had started here. She gave it to her mother (lucky mother!).
Melissa quilted this on her sewing machine. She jumped right in at quilting her creations and has done an excellent job!
A close-up of the back.
Melissa made this quilt for her husband, Joe, for his birthday. She said, "It is random and it was really quick and fun to make."
This is a quilt I started about 3 years ago, I collected the 
This was a pattern I found in the March 2007 issue of Quick Quilts magazine. I completed the top in 2007 (using fabrics that had hearts in them) and finally had Cathy quilt it in 2009. I just finished binding it and now have it up in time for Valentine's Day. Yeah!
I had left-over scraps from another heart quilt (that still needs to be quilted), so I used them in making the hearts.
Thanks for all of your advice.
This is the end result.
My girls LOVE to show everyone the pillows that they designed. 
I just made a basic Log Cabin. I cut all of my bright scraps/stash fabrics into 2.5 inch strips (or you could use a jelly roll). I started with a square 2.5 x 2.5 and added to it, sewing, cutting, ironing, sewing, cutting, ironing. I put a square of white as my last log cabin layer. I made 63 of these blocks and sewed them together in rows of 7 by 9. That's it. 
I made these two quilt tops for the new girl's room. 
we're re-doing my girls' room
Cabin Tracks was a fun, but time-consuming quilt. It uses lots of scraps--especially strips. This is the first quilt I had my friend Cathy quilt on her computerized long-arm; otherwise, it would still be in the stash of all my finished, but unquilted quilt tops! I entered it into our county fair this fall (2008) and got a blue ribbon. I was pleased! The pattern is from a 2003 Quilt Sampler magazine, made by the Stitcher's Crossing, a quilt shop in Madison, Wisconsin.
